Substance Use Treatment in Rochester, MN

Mayo Clinic

What Does Mayo Clinic Offer?

Mayo Clinic is a substance use treatment facility at 1216 2nd Street SW, Generose 1 East, Rochester, Minnesota, offering residential treatment, intensive outpatient and outpatient treatment. It accepts private insurance, TRICARE, IHS/tribal funds and self-pay. Medication treatment: buprenorphine and naltrexone.

Reviewed by Michael Rupe ·October 2, 2026

1216 2nd Street SW, Generose 1 East
Rochester, MN 55902

Listed in SAMHSA's FindTreatment.gov, checked October 2026. A listing is not an endorsement. Call to confirm services, openings and costs before you go.

Loading map…

Treatment facility (SAMHSA listing)This facility

Types of Care at Mayo Clinic

Outpatient
Residential/24-hour residential
Intensive outpatient treatment
Outpatient methadone/buprenorphine or naltrexone treatment
Regular outpatient treatment
Short-term residential

Payment, Insurance and Help Paying

IHS/Tribal/Urban (ITU) funds
Federal military insurance (e.g., TRICARE)
Private health insurance
Cash or self-payment

Medication Treatment

Buprenorphine maintenance
Prescribes buprenorphine
Prescribes naltrexone
Relapse prevention with naltrexone
Lofexidine or Clonidine detoxification
Maintenance service with medically supervised withdrawal after stabilization
Acamprosate (Campral®)
Disulfiram
Buprenorphine sub-dermal implant
Buprenorphine with naloxone
Buprenorphine without naloxone
Buprenorphine (extended-release, injectable)
Naltrexone (oral)
Naltrexone (extended-release, injectable)
Lofexidine
Clonidine

Who the Program Serves

Clients with co-occurring mental and substance use disorders
Ages: Young Adults
Ages: Adults
Ages: Seniors
Accepts: Female
Accepts: Male

Language Services

Sign language services for the deaf and hard of hearing

Licensing and Accreditation

State substance use treatment agency
State mental health department
State department of health
The Joint Commission

Treatment Approaches

Cognitive behavioral therapy
Motivational interviewing
Matrix Model
Relapse prevention
Substance use disorder counseling
12-step facilitation

Assessment, Recovery Support and Other Services

Comprehensive mental health assessment
Comprehensive substance use assessment
Complete medical history/physical exam
Screening for tobacco use
Screening for substance use
Screening for mental disorders
Professional interventionist/educational consultant
Aftercare/continuing care
Discharge Planning
Naloxone and overdose education
Outcome follow-up after discharge
Self-help groups
Housing services
Employment counseling or training
Case management service
Early intervention for HIV
Mental health services
Social skills development
Integrated primary care services
Suicide prevention services
Breathalyzer or blood alcohol testing
Drug and alcohol oral fluid testing
Drug or alcohol urine screening
HIV testing
STD testing
TB screening
Metabolic syndrome monitoring
Testing for Hepatitis B (HBV)
Testing for Hepatitis C (HCV)
Hepatitis A (HAV) vaccination
Hepatitis B (HBV) vaccination

Before you commit, confirm openings, costs and the program's state license. How to choose a rehab you can trust lists the questions to ask when you call, and addiction treatment in Minnesota lists the state's treatment agency.